Ketamine is a dissociative anesthetic that works by binding to the N-methyl-D-asparate (NMDA) receptor in the brain to block glutamate.  Glutamate is a neurotransmitter that has been linked to depression, and blocking it can lead the brain to form new connections and repair damaged ones, increasing its adaptability.  Ketamine can also work on opioid receptors to reduce pain sensations, block some sodium and potassium channels, and increase the amount of gamma-aminobutyric acid A (GABA) in the brain. Research shows that 79% of patients who haven’t responded to antidepressants respond to ketamine, which results in neurogenesis and neuroplasticity in the brain for 72 hours. ​

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Ketamine: Fast-Acting Mental Health Treatment

🧠 How It Works

• Blocks NMDA receptors, reducing glutamate to promote neuroplasticity and neurogenesis.

• Also affects opioid receptors, GABA-A, and ion channels for pain relief and calming effects.

Key Uses

• Depression: Rapid relief, especially in treatment-resistant cases; effects within hours.

• OCD: Short-term symptom relief; may need repeated doses.

• PTSD: Infusions can reduce symptoms for several weeks.

• Addiction: Helps reduce cravings for alcohol and cocaine (best with therapy).

• Opioid Withdrawal: Eases symptoms and cravings.

• Chronic Pain: Effective for nerve pain and CRPS when other treatments fail.